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Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 99-100

Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract

Correspondence Address:
R R Chattopadhyay

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Source of Support: None, Conflict of Interest: None

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Effect of Azadirachta indica (A.indica) leaf extract on inflammatory oedema induced by chemical mediators (5-HT, histamine, bradykinin and PGE1) was studied to find out its possible mechanism of reported antiinflammatory effect against carrageenin induced rat hind paw oedema. The test material showed significant antiinflammatory effect against 5-HT and PGE1 induced inflammation but not on the inflammation induced by histamine and bradvkinin. Median effective doses of A.indica for 5-HT and PGE1 induced oedema were 1.17g and 930 mg/ kg respectively. The result suggests that A.indica extract's antiinflammatory effect may be due to antagonism of the deleterious effect of 5-HT and PGE1 on blood vessels.


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