| SHORT COMMUNICATION |
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| Year : 1993 | Volume
: 25
| Issue : 2 | Page : 99-100 |
Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract
RR Chattopadhyay, RN Chattopadhyay, SK Maitra
Correspondence Address:
R R Chattopadhyay
 Source of Support: None, Conflict of Interest: None  | Check |
Effect of Azadirachta indica (A.indica) leaf extract on inflammatory oedema induced by chemical mediators
(5-HT, histamine, bradykinin and PGE1) was studied to find out its possible mechanism of reported antiinflammatory effect against carrageenin induced rat hind paw oedema. The test material showed significant antiinflammatory effect against 5-HT and PGE1 induced inflammation but not on the inflammation induced by histamine and bradvkinin. Median effective doses of A.indica for 5-HT and PGE1 induced oedema were 1.17g and 930 mg/ kg respectively. The result suggests that A.indica extract's antiinflammatory effect may be due to antagonism of the deleterious effect of 5-HT and PGE1 on blood vessels.
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