| RESEARCH PAPER |
|
| Year : 1993 | Volume
: 25
| Issue : 2 | Page : 95-98 |
Studies on diuretic effect of ST-93: A clonidine analog
R Kaushal, RM Tripathi, A Veeranjaneyulu, A Krishnamurthy, GS Thapar, RK Varma
Correspondence Address:
R Kaushal
 Source of Support: None, Conflict of Interest: None  | Check |
ST-93 induced significant diuresis in rats. Dose-dependent effects were observed in urine volume and electrolyte excretion. Dose-related natriuretic and chloruretic activities were noticed. Prazosin and yohimbine significantly antagonised diuresis of ST- 93, while propranolol, cimetidine, cyproheptadine, naloxone and bicuculline had no such effect. The data suggest the possible involvement of both alpha-l and alpha-2 adrenoceptors in the diuretic effect of ST 93 in rats.
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