IPSIndian Journal of Pharmacology
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Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 83-87

Utilisation pattern of drugs in epilepsy and factors influencing reactions to commonly prescribed drugs - A study in South Indian patients

Correspondence Address:
A Kuruvilla

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Drug utilisation pattern and incidence of reactions of commonly prescribed antiepileptic drugs in a group of patients are analysed. Incidence of reactions in this group is 27.4%. Most commonly prescribed drugs are phenobarbitone, phenytoin and carbamazepine. Number of drugs prescribed, age of patients and dose of drugs are the factors influencing the occurrence of reactions. Major reactions to phenobarbitone are related to central nervous system such as headache, drowsiness and giddiness. Gum hyperplasia is the commonest reaction reported by patients on phenytoin therapy. Cognltive functions are influenced by both phenobarbitone and phenytoin. Ataxia, nystagmus and slurred speech are the disturbing reactions caused by phenytoin.


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