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Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 78-82

Alterations in immediate and recent memory following acute oral and chronic inhalational exposure to methylparathion in rats

Correspondence Address:
George Jennifer

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The effect of organophosphorous compounds on memory, both immediate and recent, were studied in the rat. Following acute oral or chronic inhalational exposure to methylparathion (MPT), rats were tested in a complex maze. Acute oral exposure was found to compromise recent memory function but not immediate memory function. After chronic inhalational exposure, no significant alterations in either recent or immediate memory functions were detected. The negative findings of this study may be genuine or may necessitate modifications in the memory task to more sensitively identify deficits. The modifications suggested are limitations of the maze-familiarization period, and use of a spaced-learning model instead of a massed-learning task model.


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