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Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 101-102

Effect of 7,8,9,10-tetrahydroazepino (2,l -b)-quinazoline-12 (6H), one, a new antiasthmatic compound on reproduction in rat and rabbit

Correspondence Address:
G S Pahwa

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Reproductive studies of an antiasthmatic compound, 7,8,9-1 0- tetrahydroazepino (2,1 -b)-quinazoline- 12 (6H)-one were carried out as a prelude to clinical trials. Compound was devoid of any adverse effect on male and female fertility. There was no specific effect of treatment on gestation length. litter size and birth weight of pups in teratogenic studies in rats and rabbits. Prenatal and postnatal studies in rats revealed no untoward effect The compound seems to be free from any adverse effect on reproductive system


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