IPSIndian Journal of Pharmacology
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Year : 1993  |  Volume : 25  |  Issue : 1  |  Page : 34-36

Hepatoprotective effect of Tephrosia purprea in experimental animals

Correspondence Address:
Ramamurthy M Sree

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Source of Support: None, Conflict of Interest: None

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Tephrosia purpurea, known as Sarapunkha in Ayurveda for its hepatoprotective action, was evaluated for its efficacy in rats by inducing hepatotoxicity with D-galactosamine HCI (acute) and carbon tetrachloride (chronic). Tephrosia purpurea (aerial parts) powder was administered orally at a dose of 500 mgkg. Serum levels of transaminases (SGOT and SGPT) and bilirubin were used as the biochemical markers of hepatotoxicity. Histopathological changes in the liver were also studied. The results of the study indicated that the administration of Tephrosia purpurea along with the hepatotoxins offered a protective action in both acute (D- galactosamine) and chronic (CCl4) models.


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