IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3996 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded135    
    Comments [Add]    

Recommend this journal


Year : 1993  |  Volume : 25  |  Issue : 1  |  Page : 30-33

Local anesthetic activity of some basicamide compounds

Correspondence Address:
N A Kalra

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Basic amide hydrochloride compounds were found to be potent local anesthetics (100% potency), with onset of action comparable with lignocaine. Within a series, duration of anesthesia was found to increase with the increase in hydrocarbon chain length attached to "thio" moiety. Compounds B to E and H which were found to be potent local anesthetics, also possessed potent vasoconstrictor activity. The correlation coefficient between vasoconstridor activity and duration of local anesthetic activity was found to be 0.6. The Ld50 values as determined by acute toxicity studies in mice was greater than 22.4 mg/kg. Our data suggest that basicamide HCI compounds with "thio" moiety possess local anesthetic agent of greater potency and duration.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow