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Year : 1993  |  Volume : 25  |  Issue : 1  |  Page : 24-29

Assessment of behavioural tolerance to monocrotophos toxicity in albino rats

Correspondence Address:
K V Swamy

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Source of Support: None, Conflict of Interest: None

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Development of behavioural tolerance to the organophosphate insecticide, monocrotophos was assessed in male albino rats. Development of tolerance was indicated by the disap-pearance of most of the signs of toxicity and the onset times of recovery in body weights, food and water intake. The signs of toxicity were mainly cholinergic. Tolerance occurred despite continued inhibition of striatal acetylcholinesterase (AChE) activity throughout the period of investigation (16 days). The degree of AChE inhibition, however, was progressively reduced upto 16 days which could be attributed to de novo synthesis of AChE. The doses of 4.5 and 6.0 mg/kg/day were found to be effective in inducing behavioural tolerance during 16 days of daily treatment. The present study indicates that continued exposure to monocrotophos decreases the body weights and intake of food and water, and tolerance develops to this inhibition and behavioural effects in due course.


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