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Year : 1993  |  Volume : 25  |  Issue : 1  |  Page : 18-23

Opioidergic regulation of food intake: Modulation by vasopressin

Correspondence Address:
K Gulati

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Source of Support: None, Conflict of Interest: None

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Effects of acute and chronic administration of '- and k-opioid receptor agonists, morphine (MOR) and ketocyclazocine (KCZ), on food intake and their interaction with neuro-hypophysial neuropeptide, argininea8-vasopressin (AVP) have been investigated in rats. After single administration both MOR and KCZ (1 'g/rat, icv) enhanced food intake, measured for 6 h during the light phase. The responses were reversible by respective antagonists, naltrexone and Mr2266. However, after chronic administration the responses were differentially modified, i.e., there was a further enhancement of hyperphagic effect of MOR, whereas tolerance developed to this response of KCZ. AVP (0.1 'g/rat, icv) per se, did not significantly affect the food intake response. However, pretreatment with AVP attenuated the hyperphagic response to single administration of MOR or KCZ. On chronic treatment AVP (a) blocked the accentuation of hyperphagic response to MOR and (b) facilitated the attenuation of hyper-phagic response to KCZ.Results are discussed in the light of complex opioid - AVP interaction during food intake in rats.


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