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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 235-237

Effects of nonsteroidal anti-inflammatory agents on implantation in rats

Correspondence Address:
M R Marathe

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Source of Support: None, Conflict of Interest: None

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Six different non-steroidal anti-inflammatory agents were administered orally at various doses to pregnant Wistar rats from day l-6 of gestation. Observations were made on number of implantations, preimplantation deaths, resorptions, live pups and corpora lutea. Aspirin (100 and 200 mg/kg), indomethacin (1 and 2mg/kg), oxyphenbutazone (100 and 200 mg/kg), ibuprofen (100 and 200 mg/kg) and mefenamic acid (50 and 100 mg/kg) did not show any significant effect on implantation. Significant increase in the number of pre-implantation deaths was observed in ketoprofen (10 mg/kg) treated animals.


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