| SHORT COMMUNICATION |
|
| Year : 1992 | Volume
: 24
| Issue : 4 | Page : 235-237 |
Effects of nonsteroidal anti-inflammatory agents on implantation in rats
MR Marathe, GP Thomas
Correspondence Address:
M R Marathe
 Source of Support: None, Conflict of Interest: None  | Check |
Six different non-steroidal anti-inflammatory agents were administered orally at various doses to pregnant Wistar rats from day l-6 of gestation. Observations were made on number of implantations, preimplantation deaths, resorptions, live pups and corpora lutea. Aspirin (100 and 200 mg/kg), indomethacin (1 and 2mg/kg), oxyphenbutazone (100 and 200 mg/kg), ibuprofen (100 and 200 mg/kg) and mefenamic acid (50 and 100 mg/kg) did not show any significant effect on implantation. Significant increase in the number of pre-implantation deaths was observed in ketoprofen (10 mg/kg) treated animals.
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