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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 233-234

Comparative studies of the effects of calcium channel blockers on isolated skeletal muscle preparation

Correspondence Address:
R N Chattopadhyay

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Source of Support: None, Conflict of Interest: None

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Effects of calcium channel blockers on acetylcholine induced contraction on isolated frog-rectus abdominis muscle were studied. Nifedipine produced neither stimulation nor inhibition of the contraction. Verapamil and diltiazem exerted significant inhibitory effect and the inhibitory effect was surmountable in lower doses only. It is concluded that calcium channel blockers induced inhibition is at least partly due to the blockade of action of acetylcholine at the postsynaptic region.


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