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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 231-232

A comparative study of the bronchodilator activity of the calcium channel antagonists on histamine induced bronchospasm in guinea pigs

Correspondence Address:
E Abraham

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Source of Support: None, Conflict of Interest: None

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Effects of nifedipine, verapamil and diltiazem on airway smooth muscle contractility was compared in guinea pigs using the histamine aerosol test. A dose dependent bronchoprotec-tive effect was observed in nifedipine, verapamil and diltiazem pretreated animals. The equipotent doses of nifedipine (ED50 = 62 'g/kg), and diltiazem (ED50 = 68 'g/kg) were similar, while that of verapamil was noticeably smaller (ED50=34(g/kg).


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