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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 223-226

Cardiac effects of calcium channel blockers in human volunteers

Correspondence Address:
P Sharma

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Source of Support: None, Conflict of Interest: None

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The effects of oral nifedipine (NFD, 10 mg), verapamil (VPL, 80 mg) and diltiazem (DLZ, 60 mg) on supine heart rate (HR), blood pressure (BP) and systolic time interval (STI) were compared in a double blind cross-over study in 6 normal volunteers. STI was calculated by serial recording of ECG, carotid pulse and phonocardiogram before and 15, 30, 60 and 120 min. following drug intake. There was a fall in systolic and diastolic BP and the ratios of pre-ejection period-and left ventricular ejection time were significantly reduced with the three CCBs when compared to pretreatment values. HR was significantly increased by NFD but reduced by both VPL and DLZ. Maximum effect in all parameters recorded was obtained at 30 min. Side effects were assessed by questionnaire with all the drugs.


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