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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 201-206

Effect of some oral antidiabetic drugs on glucose and mineral metabolism in alloxan diabetic rats pretreated with ethylene diamine tetraacetic acid disodium salt

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AAE Shoka

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Effect of disodium ethylenediamine tetraacetate (EDTA) in the presence or absence of phenformin or glibenclamide on blood glucose level, plasma and urinary mineral ion contents, in normal and alloxan diabetic rats was investigated. It induced slight hyper glycemia and increased the plasma sodium content of normal and alloxan diabetic rats. However both plasma potassium and calcium contents were decreased. The plasma calcium content was significantly decreased after administration of EDTA in association with each antidiabetic drug in normal animals. All investigated drugs variably reduced plasma iron content, Hypoglycemia induced by phenformin or glibenclamide was associated with elevation of plasma chromium ions. However, plasma copper ions changes induced by EDTA seem to be unrelated to hypoglycemia induced by glibenclamide or phenformin. Reduction of plasma iron content was related to hypoglycemia induced by tested drugs. Reduction of zinc ion in the plasma was associated with hypoglycemia induced by phenformin.


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