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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 197-200

A comparative study of the convulsive properties of antidepressants

Correspondence Address:
Aggarwal Renu

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Source of Support: None, Conflict of Interest: None

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The proconvulsant and anticonvulsant effects of acute and chronic exposure to antidepressants were investigated in adult rats. None of the antidepressants (trazodone, doxepin, imipramine and maprotiline) under study, could abolish pentylene tetrazole (PTZ) or picrotoxin induced convulsions. The effects on convulsive threshold in both chemoshock and maximal electroshock seizures (MES) were partial. The antidepressants exhibited a trend towards anticonvulsant activity against PTZ and MES induced seizures and an opposite pattern (proconvulsant action) against picrotoxin induced convulsions. No appreciable differences were observed in response to acute and chronic treatment schedules. Within limitations of the present study, doxepin and maprotiline appear to have least chances of seizure episodes during antidepressant therapy.


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