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Year : 1992  |  Volume : 24  |  Issue : 3  |  Page : 174-175

Verapamil - A potential ocular hypotensive agent

Correspondence Address:
S K Gupta

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Source of Support: None, Conflict of Interest: None

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The ocular hypotensive effect of a single topical application of verapamil was studied in albino rabbits. In normotensive rabbits, after base line measurement of intraocular pressure (IOP) with applanation tonometer, 30 'l drops of verapamil in the concentration of 0.125% was instilled in one eye while contra-lateral eye received the vehicle and served as control. The IOP measurements were taken at 30 min., 2, 4 and 8 hrs. The onset of pressure lowering effect was observed at 30 minutes, with a peak effect at two hours and persisted up to 8 hrs. The hypotensive effect of verapamil was also studied after water loading in twelve rabbits. The reduction of pressure was more marked (6r1.20 vs 4˝ 0.14 mm Hg) in water loaded rabbit's eyes as compared to normotensive eyes which was statistically significant (P < .001) when compared with base line values and with the contralaterarcontrol eyes.


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