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Year : 1992  |  Volume : 24  |  Issue : 3  |  Page : 166-168

Plasma disposition and biodistribution studies on gentamicin in rabbits

Correspondence Address:
R P Uppal

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Source of Support: None, Conflict of Interest: None

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The plasma disposition biodistribution and dosage regimens of gentamicin were studied in rabbits tollowing i.v. administration (4 mg/Kg). The distribution and elimination half-life values were calculated to be 0.38˝ 0.07 and 2.88˝ 0.33 h, respectively. The concentration of gentamicin was found to be highest in kidneys, both at 10 min and 1 h while adrenals revealed absence of the drug. Based on kinetic parameters, satisfactory i.v. dosage regimens of gentamicin in rabbits would be 10.02 and 8.71 mg/Kg as the loading and maintenance doses, respectively, to be repeated at 8 h intervals.


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