| SHORT COMMUNICATION |
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| Year : 1992 | Volume
: 24
| Issue : 3 | Page : 166-168 |
Plasma disposition and biodistribution studies on gentamicin in rabbits
RP Uppal, Garg Satish, SP Verma, RK Roy
Correspondence Address:
R P Uppal
 Source of Support: None, Conflict of Interest: None  | Check |
The plasma disposition biodistribution and dosage regimens of gentamicin were studied in rabbits tollowing i.v. administration (4 mg/Kg). The distribution and elimination half-life values were calculated to be 0.38ñ 0.07 and 2.88ñ 0.33 h, respectively. The concentration of gentamicin was found to be highest in kidneys, both at 10 min and 1 h while adrenals revealed absence of the drug. Based on kinetic parameters, satisfactory i.v. dosage regimens of gentamicin in rabbits would be 10.02 and 8.71 mg/Kg as the loading and maintenance doses, respectively, to be repeated at 8 h intervals.
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