IPSIndian Journal of Pharmacology
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Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 126-127

Effects of drugs on mucociliary activity in humans

Correspondence Address:
S U Vora

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Source of Support: None, Conflict of Interest: None

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The mucociliary transport system is an important defense mechanism of the body. Many diseases that can affect the bronchial tract may impair this system and many pharmacological agents may alter mucociliary activity. Because of the importance of this system, it was thought to be interesting to study mucociliary transport time in healthy volunteers and the effects of ibuprofen, erythromycin and theophylline on the same. Seven volunteers were selected for studying the effect of theophylline, and 20 volunteers were selected for studying the effects of ibuprofen and erythromycin, 10 volunteers for each drug. It was found that theophylline significantly improved ciliary function, whereas ibuprofen and erythromycin did not Influence ciliary function to a great extent.


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