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Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 123-125

Pharmacokinetics of amikacin sulphate in goats

Correspondence Address:
R P Uppal

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Source of Support: None, Conflict of Interest: None

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Pharmacokinetics of amikacin sulphate in goats was investigated following single i.v. injection of 10 mg/kg. Distribution and elimination half-lives and apparent volume of distribution values were 15.7 min, 130.1 min and 0.40 I/kg, respectively. At 6 h after the administration of drug, 10.2 percent was in the central and peripheral compartments and about 90 percent had been eliminated. To produce an average steady-state plasma amikacin concentration within the therapeutic range, a dosage of 10 mg of amikacin per kg, at 12 h interval, is recommended.


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