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Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 121-122

5-HT link in imipramine induced hypothermia in rabbits

Correspondence Address:
A K Srivastava

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Source of Support: None, Conflict of Interest: None

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The effect of imipramine and 5-HT linked agents on body temperature was studied in rabbits. The drugs were administered intracerebroventricularly (icv) and rectal temperature was recorded. Graded doses of imipramine produced dose related hypothermia. Methysergide (200 'g icv) alone produced hyperthermia and completely blocked the hypothermia produced by 500 'g of imipramine. The pretreatment with p-chlorophenylalanine (25 mg/day, i.p; 3 days) completely abolished the hypothermia produced by 500'g of imipramine. It appeared that 5-HT is involved in the production of hypothermia induced by imipramine.


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