IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 775 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 ╗   Next article
 ╗   Previous article
 ╗   Table of Contents

Resource Links
 ╗   Similar in PUBMED
 ╗  Search Pubmed for
 ╗  Search in Google Scholar for
 ╗Related articles
 ╗   Citation Manager
 ╗   Access Statistics
 ╗   Reader Comments
 ╗   Email Alert *
 ╗   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded336    
    Comments [Add]    

Recommend this journal


Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 107-110

Effect of a herbal hepatoprotective product on drug metabolism in patients of cirrhosis and hepatic enzyme function in experimental liver damage

Correspondence Address:
C K Chauhan

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

A compound herbal product, mixture of 6 herbs, advocated as a hepatoprotective and hepatocorrective agent was investigated to determine its efficacy on various hepatic enzyme functions. Since chronic hepatocellular disease is known to be associated with impaired hepatic drug metabolism, the extent of restoration by the product, if any, in hepatic drug metabolising capacity of patients of cirrhosis was studied by estimation of serum antipyrine half-life. In patients of cirrhosis 3 weeks oral treatment with this compound reduced antipyrine half-life significantly (P 0.001) from 29.3˝ 1 1 h, to 17.9˝ 0.9 h after treatment. In experimental carbon tetrachloride induced acute and chronic liver damage in rats, pretreatment with this product was effective in inhibiting triglyceride accumulation in hepatic cells and in protecting the liver against increase in hydroxyproline content.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow