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Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 102-106

Effect of sublethal daily dosing of monocrotophos on activities of aminotransferases and glutamate dehydrogenase in rat brain

Correspondence Address:
K V Swamy

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Source of Support: None, Conflict of Interest: None

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Monocrotophos, an organophosphate insecticide, was given orally in sublethal doses to male albino rats for different durations ranging from 1 h to 16 days. The effects of monocrotophos on aspartate aminotransferase (AAT), alanine aminotransferase (AIAT) and glutamate dehydrogenase (GDH) activities in different brain areas (cerebral cortex, cerebellum, hippocampus and medulla) were studied. The results showed that monocrotophos causes elevation in AAT and AlAT activities and inhibition in GDH activity. The effect was progressive as the dosing was continued. Maximum effect on these enzyme activities was seen in the cerebral cortex. The results suggest that monocrotophos is a potent neurotoxicant which affects the activities of other enzyme also, besides its cholinergic effect.


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