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Year : 1992  |  Volume : 24  |  Issue : 1  |  Page : 36-37

Disposition kinetics and dosage regimen of gentamicin in rabbits following intramuscular administration:

Correspondence Address:
R P Uppal

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Source of Support: None, Conflict of Interest: None

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Pharmacokinetics and dosage regimen of gentamicin were investigated in rabbits following a single intramuscular administration of 4mg/kg. The absorption and elimination half lives and apparent volume of distribution were 4.8˝ 0.6 min,44.4˝ 9.0 min and 0.45 ˝ 0.11 l/kg ,respectively. Therapeutic plasma levels of 1 ug/ml were maintained upto 2 h. A satisfactory intramuscular dosage regimen would be 3.48 mg/kg and 3.l0mg/kg as priming and maintenaance doses, respectively, to be repeated at 2 h intervals.


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