IPSIndian Journal of Pharmacology
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Year : 1992  |  Volume : 24  |  Issue : 1  |  Page : 32-35

The effects of pH on dopamine and serotonin synthesis by rat brain striatal synaptosomes:

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The rate of dopamine or serotonin synthesis in rat brain striatal synaptosomes was determined as a function of pH. Optimal pH for serotonin synthesis was about 7.2 and as the pH of the suspension medium decreased below 7 the rate of serotonin formation declined. Optimal pH for dopamine production was at 6.1 and when experiments were performed at pH 7.4 the rate of dopamine formation decreased to about 25% of that at pH 6.1. Addition of either dopamine or serotonin to the suspension medium inhibited the rate of dopamine and serotonin formation by the synaptosomes. lt appears that dopamine and serotonin interaction plays an important role in the control of neural function during brain pH changes. It is concluded that synaptosomes may be used as a suitable model to study the neurochemical changes of the brain during acidosis.


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