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Year : 1992  |  Volume : 24  |  Issue : 1  |  Page : 25-28

Pharmacokinetics of ciprofloxacin - limitation to salivary and urinary sampling

Correspondence Address:
C Suthakaran

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Source of Support: None, Conflict of Interest: None

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The relationship between plasma, saliva and urine ciprofloxacin concentration was investigated in 16 normal male healthy volunteers after oral administration of 750 mg. Peak plasma concentration of 4.8 mg/ I was achieved between 1 to 1.5 h after drug administration. The pharmacokinetics of ciprofloxacin in our population was not different from that reported in the literature. The salivary concentration of the drug was lower and it declined more rapidly than that in plasma. The agreement between estimations in the two biological fluids was poor. Between 15 - 38 % of the dose was recovered unchanged in urine till 12 h after drug administration. A good correlation (r =0.84; P c 0.005) was seen between creatinine clearance and renal clearance of the drug. The elimination half-life calculated using plasma , saliva and urinary levels were 6.2, 4.6 and 3.6 h respectively. It is concluded that neither saliva nor urine can be substituted for plasma sampling in pharmacokinetic studies of ciprofloxacin.


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