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Year : 1991  |  Volume : 23  |  Issue : 4  |  Page : 247-252

Evidences for the presence of dopamine receptors in iris

Correspondence Address:
Y P Srivastava

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Source of Support: None, Conflict of Interest: None

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1. Haloperidol is known to produce miosis by acting on receptors present in the iris. This study domonstrates the presence of dopamine receptors in the iris. 2. Dopamine given intracamerally produced dose-related mydriasis, and haloperidol was found to competitively antagonize this effect. 3. Apomorphine, another dopamine agonist, also produced dose-related mydriasis. 4. These observations suggest the presence of dopamine receptors in the iris. 5. Since the mydriasis was completely abolished after reserpinization and competetively antagonixed by phentolamine, it is proposed that these dopamine receptors are present presynaptically at the sympathetic nerve endings and are excitatory for norepinephrine release.


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