| RESEARCH PAPER |
|
| Year : 1991 | Volume
: 23
| Issue : 4 | Page : 214-218 |
Study of effects of oral contraceptive steroids on experimentally induced ulcers in rat stomach
K Chakravarty, BP Mukherjee
Correspondence Address:
K Chakravarty
 Source of Support: None, Conflict of Interest: None  | Check |
1. Three categories of oral contraceptive agents viz., estrogen, progestogen and combination of these two were administered p.o. to separate groups of female albino rats for graded time schedules to evaluate the effects on stress-induced gastric lesions.
2. Under estrogen regime prolongation of drug therapy afforded increasing degree of protection.
3. Progestogen was ineffective in preventing the lesions in short-term medication, but produced even grater protection than with estrogen during long-term schedule.
4. In case of combination pill therapy, the results were opposite to that of progestogen.
5. Varying degrees of effects on gastric acidity, mucus secretion and possible inhibitory influence on hypothalamic control could be responsible for the differential effects of the agents used.
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