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 RESEARCH PAPER
Year : 1991  |  Volume : 23  |  Issue : 4  |  Page : 197-201

Effects of carnitine treatment on cardiac phosphorylase and lipids in streptozotocin induced diabetic rats


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R K Goyal


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1. The effects of carnitine treatment on isoproterenol-induced activation of phosphorylase was studied in diabetic and non-diabetic rats. 2. Administration of streptozotocin (STZ) in rats caused a significant elevation of serum glucose, cholesterol and triglycerides whereas,serum insulin was significantly decreased 3. Carnitine treatment (3g/kg/day p.o.) did not alter serum-glucose or serum-insulin levels in diabetic rats, however, there was a significant decrease in serum-triglycerides and cholesterol in diabetic rats treated with carnitine. 4. An increase in triglycerides was fouud in cardiac membranes of diabetic rats. This increase was also prevented by carnitine treatment. 5. The total cardiac phosphorylase was not altered either by diabetic status or carnitine treatment. However, there was a significant increase in phosphorylase activation by isoproterenol in hearts obtained from diabetic rats. 6. Carnitine treatment failed to prevent this supersensitivity to isoproterenol-induced phosphorylase activation. 7. It is evident from the data that alterations in Ca2( homoestasis caused by diabetes may not be the cause for increased phosphorylase activation by isoproterenol in diabetic rats.






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