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Year : 1991  |  Volume : 23  |  Issue : 3  |  Page : 132-136

Antipyrine half-life in rabbits given long-term anti-tubercular therapy

Correspondence Address:
R Malhi

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Source of Support: None, Conflict of Interest: None

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1. Pharmacokinetics of Antipyrine (AP), (Single oral dose, 20 mg/kg) was studied during long-term treatment with anti-tubercular therapy. 2. Anti-tubercular therapy (ATT) with two main-line drugs i.e. Rifampin (RLF) and Isoniazid (INH) was given over a period of 45 days. AP was measured on 0, 25 and 50th day of the treatment. 3. In controls (without ATT) there was no significant difference observed at 0, 25 and 50th day in the mean plasma concentration, t1/2, Cl, Kel and AUCO 0-( 4. In test group, the mean plasma concentration was significantly decreased on the 25th day as compared to the 0 day level. 5. The Plasma half-life, clearance, elimination rate constant area under the plasma concentration time curve was found to be statistically significant on 25th day as compared to 0 day levels. No significant difference was observed between 25th and 50th day.


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