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Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 86-89

Modulation of acute neurobehavioral toxicity of aldrin by some blockers

Correspondence Address:
A K Agarwal

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Source of Support: None, Conflict of Interest: None

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1. The acute neurobehavioral toxicity of organochlorine pesticide, aldrin, has been studied at sublethal doses. 2. A dose of 8.9 mg/kg (l/4 LD50) induced piloerection, tremors, convulsive excitement restlessness, augmented spontaneous motor activity and exploratory behavior in mice after 60 min. of i. p. administration indicating CNS stimulation. 3. Blockade of specific neurotransmitter system by pretreatment with atropine (10 mg/kg), iproniazid (100 mg/kg) alpha-methyl-p-tyrosine (200 mg/kg), p-chlorophenylalanine (200 mg/kg) or thiosemicarbazide (5 mg/kg) significantly altered the neurotoxic symptoms induced by the pesticide indicating direct or indirect involvement of various neurotransmitter system in mediating CNS toxicity. 4. Conditioned avoidance response in rats was not affected by the pesticide alone or in combination with either drug.


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