| RESEARCH PAPER
|Year : 1991 | Volume
| Issue : 2 | Page : 81-85
Co-trimoxazole & co-trimazine : A comparative bioavailability study
P Mahajan, U Tekur, P Sen
1. A cross over bioavailability study was carried out with co-ttimoxazole and co-trimazine administered in a dose of 2 tab. BD and 1 tab. BD respectively for 15 doses each, in normal healthy volunteers.
2 Plasma trimethoprim concentration was higher in the co-trimoxazole treated group as compared to the co-trimazine treated group (p<0.02).
3. Serum sulfamethoxazole concentrations were higher than serum sulfadiazine concentrations in the co-trimoxazole and co-trimazine treated groups respectively.
4. The time for reaching the peak and steady state concentrations of drugs in the two treatment groups did not differ significantly for comparable drugs.
Source of Support: None, Conflict of Interest: None