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Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 109-113

Alpha, adrenoceptors : Are they involved in cardiac arrhythmias induced by intravenous aconitine ?

Correspondence Address:
G P Thomas

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Source of Support: None, Conflict of Interest: None

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1. Clonidine (6.25, 12.5 and 25 'g/kg) and yohimbine (0.25,0.5 and 1 mg/kg) were studied for their effects on aconitine induced cardiac arrhythmias. 2. Initial abnormal rhythm and ventricular tachycardia were induced by intravenous infusion of aconitine in rats. 3. Pretreatment with doses of clonidine and yohimbine which are selective to (( adrenoceptors failed to alter time of onset of initial arrhythmia and ventricular tachycardia, whereas quinidine (10 mg/kg) exhibited significant antiarrhythmic effect by delaying the time of onset of both the arrhythmic stages.


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