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Year : 1990  |  Volume : 22  |  Issue : 4  |  Page : 207-210

Assessment of the tolerability of hydroxy-propyl methyl cellulose in two different vehicles in rabbit eyes.

Correspondence Address:
V B Sovani

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Source of Support: None, Conflict of Interest: None

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1. 2% solutions of locally manufactured Hydroxypropyl methyl cellulose [HPMC) in Balanced Salt Solution (BSS) or Ringer Lactate (RL) with or without a colouring agent were tested for tolerability in rabbit eyes, in four sets of 6 rabbits each. 2. Aqueous was aspirated and replaced in the left eye with HPMC solution, the right eye served as control. The eye was examined for inflammation daily for 10 days, while intraocular pressure (IOP) was measured on days 1, 2, 5 and 10. 3. Over 10 days observation period the eyes were clinically normal. There was no bacterial growth in aqueous on culture and no signs of inflammation on histopathology in eye on day 10.The IOP showed a significant fall, but the absolute difference in the means was only 0.5 mm of Hg. It is concluded that 2% HPMC in both BSS and RL with or without a colouring agent is well tolerated in the rabbit eye.


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