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Year : 1990  |  Volume : 22  |  Issue : 4  |  Page : 202-206

Effect of antibiotics on neonatal polymorphonuclear leucocyte function in vitro

Correspondence Address:
S S Kamdar

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Source of Support: None, Conflict of Interest: None

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1. A micromethod requiring a few drops of blood was used to measure simultaneously neutrophil phagocytosis and bactericidal activity in ten preterm neonates, ten full term normal healthy neonates and ten normal adult volunteers. 2. The in-vitro effect of three antibiotics erythromycin, gentamicin and chloramphenicol on the neutrophil phagocytic and bactericidal function was assessed after incubating the antibiotics with the cells from neonates and adults. 3. As opposed to adults, wherein erythromycin enhanced phagocytosis by the polymor-phonuclear leukocytes (PMNs), no such enhancement was observed with the PMNs from preterm and normal neonates. 4. chloramphenicol and gentamicin had no effect on the PMN phagocytic function in adults and neonates. 5. The bactericidal function of PMNs from adults and neonates was found to be unaltered by all three antibiotics.


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