IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1989  |  Volume : 21  |  Issue : 4  |  Page : 144-152

A study on the selectivity of action of (+) INPEA and vasicine in different isolated tissue preparations



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1. The action of (+) INPEA and vasicine on the isolated rat uterus, guinea pig uterus, rat mammary gland, guinea pig ileum and guinea pig tracheal chain were studied. 2. (+) INPEA (1' g/ml and 10 'g/ml) and vasicine (1 'g/ml and 10 'g/ml) elicited a stimulant action, with an increase in amplitude and frequency of contractions in the isolated rat and guinea pig uterus. 3. Vasicine (1 'g/ml) potentiated the action of oxytocin in isolated rat mammary strip preparation. 4. Vasicine (1 'g/ml) potentiated the action of barium chloride evoked contractions in guinea pig ileum. 5. The study indicates that ( + ) INPEA shows selectivity for uterine tissue.






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