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 RESEARCH PAPER
Year : 1989  |  Volume : 21  |  Issue : 4  |  Page : 135-143

Peripheral markers for neurotoxic diseases blood platelet receptors



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K Seth


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1. Blood platelet 3H-spiperone binding sites in patients suffering from hyperkinesia, mental retardation and Parkinson's disease were significantly altered and showed a close relationship with the clinical findings. 2. Exposure of rats to neurotoxicants methyl mercury chloride (0.4 or 4.0 mg/kg) or methyl methacrylate (250 or 500 mg/kg) resulted in changes in the binding characteristics of 3H-spiperone which were similar in blood platelets and brain tissues. 3. The similar behaviour of 3H-spiperone and 3H-5HT binding sites in blood platelet and neuronal tissue in the above mentioned diseases and on exposure to some neurotoxic chemicals indicate that blood platelets could serve as a useful peripheral model for studying neurological disorders after further validation.






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