| RESEARCH PAPER
|Year : 1989 | Volume
| Issue : 4 | Page : 135-143
Peripheral markers for neurotoxic diseases blood platelet receptors
K Seth, PK Seth
1. Blood platelet 3H-spiperone binding sites in patients suffering from hyperkinesia, mental retardation and Parkinson's disease were significantly altered and showed a close relationship with the clinical findings.
2. Exposure of rats to neurotoxicants methyl mercury chloride (0.4 or 4.0 mg/kg) or methyl methacrylate (250 or 500 mg/kg) resulted in changes in the binding characteristics of 3H-spiperone which were similar in blood platelets and brain tissues.
3. The similar behaviour of 3H-spiperone and 3H-5HT binding sites in blood platelet and neuronal tissue in the above mentioned diseases and on exposure to some neurotoxic chemicals indicate that blood platelets could serve as a useful peripheral model for studying neurological disorders after further validation.
Source of Support: None, Conflict of Interest: None