| RESEARCH PAPER |
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| Year : 1989 | Volume
: 21
| Issue : 3 | Page : 73-80 |
Some pharmacokinetic aspects of sulphacetamide, sulphadimidine and sulphanilamide in West-African Dwarf (WAD) goats
SN Shetty, IU Asuzu
Correspondence Address:
S N Shetty
 Source of Support: None, Conflict of Interest: None  | Check |
1. Pharmacokinetic studies of sulphacetamide (SAC), sulphadimidine (SDM) and sulphanilamide (SNL) were conducted in West African Dwarf (WAD) goats injected iv at dose rate of 50 mg/kg.
2. The semilogarithmic graph of plasma concentration-time profile of these sulphonamides exhibited biphasic decline suggestive of 2-compartment open model kinetics.
3. The mean elimination half life of SAC and SNL, was 1.88 and 4.39 h respectively; however, it was 3.04 and 11.06 h respectively for goats with fast and slow SDM-disposition.
4. The respective apparent volume of distribution, Vd (area) of SAC and SNL was 0.87 and 0.48 l/kg; for SDM it was 0.33 and 0.29 l/kg for animals with fast and slow SDM disposition.
5. The approximate degree of in vitro and in vivo binding of SAC (12-16%) and SNL (22- 24%) to plasma protein was independent of drug concentration whereas that of SDM showed inverse relationship with drug concentration (40 and 60% binding with 300 and 10 'g/ml).
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