| SHORT COMMUNICATION |
|
| Year : 1989 | Volume
: 21
| Issue : 3 | Page : 104-106 |
Modification of histamine induced wheal suppression method and its utility in bioassay of topical steroids
PK Singh, G Singh
Correspondence Address:
P K Singh
 Source of Support: None, Conflict of Interest: None  | Check |
1. Histamine induced wheal suppression technique of Reddy and Singh (1976) has been modified by calculating volume of the wheal.
2. Height of the wheal was measured with the help of a spherometer to calculate its volume by the relation (r2h.
3. Potency of two topical corticosteroid preparations (halcinonide 0.1% and hydrocortisone l .0%) was assessed on ten healthy volunteers in a double blind study.
4. The effect of tachyphylaxis was observed with both the steroids within a week, still earlier with potent steroid.A four days rest was enough to bring back the skin to its pretreatment level.
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