| SHORT COMMUNICATION
|Year : 1989 | Volume
| Issue : 2 | Page : 46-50
A note on neuropsychopharmacological studies of Melia azedarach leaves
Verma Sandeep, ME Hamdard, PC Dandiya
1. Melia azedarach leaf extract potentiated pentobarbitone induced hypnosis in mice, lowered activity in the open field, decreased conditioned avoidance response and Techno wheel activity in rats, thus indicating a CNS depressant property.
2. It showed analgesic action as seen by the hot plate and also the acetic acid induced writhing method.
3 . It potentiated haloperidol induced catatonia, reduced the immobility of rats enhanced exploratory activity but like other CNS depressants (e.g. phenobarbitone) it reduced seizures.
4. It did not provide any protection against amphetamine toxicity in aggregated mice.
Source of Support: None, Conflict of Interest: None