| RESEARCH PAPER
|Year : 1989 | Volume
| Issue : 2 | Page : 31-37
Mechanism of acute pressor response to cadmium chloride
R Balaraman, OD Gulati, JD Bhatt, SP Rathod, KG Hemavathi
1. In rats, acute iv administration of CdCl2 (0.5 and 1 mg/kg) produced a depressor response followed by a pressor response while the acute i p administration of CdCI2 (0.5 and 1 mg/kg) produced only a pressor response.
2. Hexamethonium (10 mg/kg, i v), phentolamine (5 mg/kg, i v), propranolol (2 mg/kg, i v) or indomethacin (20 mg/kg, i p) did not modify the acute pressor response to CdCl2 (i v or i p).
3. Acute reserpinisation, bilateral adrenalectomy or chemical sympathectomy by guanethidine did not modify the acute pressor response to CdCI2 (i v or i p).
4. Verapamil(0.5, 1 and 2 mg/kg, i v) or nifedipine (0.25 and 0.5 mg/kg, i v) prevented the acute pressor response to CdCl2 (i v or i p).
5. It is concluded that cadmium might mimic calcium ion and produce a direct contractile effect on the vascular smooth muscle.
Source of Support: None, Conflict of Interest: None