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Year : 1989  |  Volume : 21  |  Issue : 2  |  Page : 31-37

Mechanism of acute pressor response to cadmium chloride

Correspondence Address:
R Balaraman

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Source of Support: None, Conflict of Interest: None

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1. In rats, acute iv administration of CdCl2 (0.5 and 1 mg/kg) produced a depressor response followed by a pressor response while the acute i p administration of CdCI2 (0.5 and 1 mg/kg) produced only a pressor response. 2. Hexamethonium (10 mg/kg, i v), phentolamine (5 mg/kg, i v), propranolol (2 mg/kg, i v) or indomethacin (20 mg/kg, i p) did not modify the acute pressor response to CdCl2 (i v or i p). 3. Acute reserpinisation, bilateral adrenalectomy or chemical sympathectomy by guanethidine did not modify the acute pressor response to CdCI2 (i v or i p). 4. Verapamil(0.5, 1 and 2 mg/kg, i v) or nifedipine (0.25 and 0.5 mg/kg, i v) prevented the acute pressor response to CdCl2 (i v or i p). 5. It is concluded that cadmium might mimic calcium ion and produce a direct contractile effect on the vascular smooth muscle.


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