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Year : 1989  |  Volume : 21  |  Issue : 2  |  Page : 16-21

Potential antifilarial activity of Streblus asper against Setaria cervi (nematoda: filarioidea)

Correspondence Address:
Parveen Nazneen

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Source of Support: None, Conflict of Interest: None

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The effect of aqueous and alcoholic extract of Streblus asper was studied on the spontaneous movements of the whole worm and nerve-muscle preparation of Setaria cervi and on the survival of microfilariae in vitro. Aqueous as well as alcoholic extract caused inhibition of spontaneous motility of the whole worm and the nerve-muscle preparation of S cervi characterized by decreased tone, amplitude and rate of contractions. The concentration required to inhibit the movements of the nerve-muscle preparation was l/25 for aqueous and l/160 for alcoholic extract suggesting a cuticular permeability barrrier. The stimulatory response of acetylcholine was blocked by alcoholic and not by aqueous extract of S asper. Both alcoholic as well as aqueous extracts caused death of microfilariae in vitro, LC50 and LC90 being 90 and 33.5 ng/ml, respectively.


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