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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 95-101

Cytotoxic and tumour reducing properties of curcumin

Correspondence Address:
K K Soudamini

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Source of Support: None, Conflict of Interest: None

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1. curcumin which is the active ingredient in turmeric was found to be cytotoxic to various cell lines in vitro at concentrations 8(g/ml or more. Complete disintegration of cells could be seen upon incubation with higher concentration (50(/ml) of curcumin. 2. Due to the insolubility of curcumin. liposomally encapsulated curcumin wee prepared which showed the same acvitiy es curcumin in tissue culture. 3. Roth curcumin end liposmally encepeulsted curcumin inhibited the tritisted thymidine incorporation into DNA. Liposomally encapsulated curcumin also inhibited ascites tumour formation in mice induced with Dalton's lymphoma ascites tumour cells. 4. Sodium curcumate. a soluble curcumin derivetive wes found to be not cyotoxic in vitro end in tissue culture. Sodium curcumate inhibited thvmidine incorporation into PNA only at higher concentration.


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