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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 90-94

Paracetamol disposition in rat after oral intake of methaqualone

Correspondence Address:
K P Gupta

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Source of Support: None, Conflict of Interest: None

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1. The effect of oral feeding of methaqualone on the pharmacokinetica of paracetamol diapoeition waa studied. 2. Rats given methaqualone (60 mg/kg) orally for a prolonged period were given in addition a single dose of paracetamol (100 mg/kg ip) and pharmacokinetic profile of paracetamol in the plasma and drug levels in liver were estimated. 3.Repeated oral methaqualone intake increased parecetamol disposition.


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