| RESEARCH PAPER |
|
| Year : 1988 | Volume
: 20
| Issue : 2 | Page : 178-181 |
ß-Lactam antibiotics: effect on barbiturate-induced hypnosis in mice
PP Singh, AY Junnarkar, KV Singh, NP Shukla
Correspondence Address:
P P Singh
 Source of Support: None, Conflict of Interest: None  | Check |
1. In the present investigation the effect of few (-Iactam antibiotics end their intermediates were studied on the barbiturate induced hypnosis in mice.
2. Sodium ampicillin, amoxicillin end 7-aminodeacetoxy cephalosporanic acid failed to inhibit herbitone-induced hypnosis and animals pretreated 2 end 12 h before did not affect the pentabarbitone sleeping time. indicating the induction of hepatic microsomal enzyme bythese agents end which is a slow process.
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