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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 178-181

▀-Lactam antibiotics: effect on barbiturate-induced hypnosis in mice

Correspondence Address:
P P Singh

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Source of Support: None, Conflict of Interest: None

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1. In the present investigation the effect of few (-Iactam antibiotics end their intermediates were studied on the barbiturate induced hypnosis in mice. 2. Sodium ampicillin, amoxicillin end 7-aminodeacetoxy cephalosporanic acid failed to inhibit herbitone-induced hypnosis and animals pretreated 2 end 12 h before did not affect the pentabarbitone sleeping time. indicating the induction of hepatic microsomal enzyme bythese agents end which is a slow process.


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