| RESEARCH PAPER
|Year : 1988 | Volume
| Issue : 2 | Page : 178-181
▀-Lactam antibiotics: effect on barbiturate-induced hypnosis in mice
PP Singh, AY Junnarkar, KV Singh, NP Shukla
1. In the present investigation the effect of few (-Iactam antibiotics end their intermediates were studied on the barbiturate induced hypnosis in mice.
2. Sodium ampicillin, amoxicillin end 7-aminodeacetoxy cephalosporanic acid failed to inhibit herbitone-induced hypnosis and animals pretreated 2 end 12 h before did not affect the pentabarbitone sleeping time. indicating the induction of hepatic microsomal enzyme bythese agents end which is a slow process.
P P Singh
Source of Support: None, Conflict of Interest: None