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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 171-174

Changes in plasma and brain tryptophan and serotonin levels following fenfluramine administration in rat

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M Ani

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1. Fe nfluramine. on ( norexogenic drug, is believed to exert itr effectvia the serotonergic system et the level of hypothalamus. Since tryptophan is the precursor of serotonin. the effect of this drug on tryptophan metabolism in the rat was investigated. 2. Serum total tryptophan level increased transientlyfollowing fenfluramine administration (10 mg/kg) for 10 days returning to the normal level despite the continuation of the treatment for long period of time up to 45 days. Furthermore, the bound fraction of this amino acid was mainly effected end the free fraction remained unchanged. 3. Brain tryptophan rose in parallel with the serum level, whereas brain serotonin level showed a significant decrease after fenfluramine injection. 4. These results explain the transient action of fenfluramine in production of anorexia and bring further, evidence to support the view that serotonergic system is involved in the mechanism of action of this agent.


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