IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 15780 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded97    
    Comments [Add]    

Recommend this journal


Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 159-166

Cholinergic effects of clonidine on the rat anococcygeus muscle preparation

Correspondence Address:
S K Gohil

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

1. The present Investigation was undertaken to study the cholinergic effects of clonidine on the isolated rat anococcygeus musIce. 2. Clonidine produced dose dependent contractions of rat anococcygeus muslce which were completely antagonised by phentolamine and atropine. 3. Sub-threshold dose of clonidine produced potentiation of carbachol and acetylcholine induced responses. but did not alter responses to noradrenaline dopamine or 5-hydroxytryptamine (5-HT). 4. Clonidine. however. failed to potentiate the carbachol induced responses on preparations which We re bathed with physiological salt solution containing low Ca++ low Na++ or niludipine. However the potentiation was maintained in PSS containing more Ca ++.yohimbine. prazosin or ouabain. 5. It is concluded that clonidine has indirect cholinomimetic effect, which involved extracellular sodium (NA+) and calcium (Ca++).


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow