| RESEARCH PAPER
|Year : 1988 | Volume
| Issue : 2 | Page : 129-134
Effects of metoclopramide and the status of dopamine receptors in rat anococcygeus muscle
VK Patel, RV Bhatt, KR Goyal
1. Dopamine produced a dose-dependent contraction of rat anococcygeus muscle. in the presence of sub-threshold dose of metoclopramide (2.8 x 1O-8 M), the responses to dopamina were potontiated.
2. Dopamineinduced contractions were competitively antagonized by haloperidol and phentolamine. Phentolamine induced inhibition of dopamine-receptors was partially uncovered by motociopramide.
3. Dopamine (1 X 10-10 M) inhibited there sponses to field stimulation which was prevented by metoclopramide.
4 . In the reserpinized anococcygeus muscle preparations the responses to dopamine were reduced significantly and metoclopramide failed to produce any potentiation of the responses.
5. The data presented suggest the presence of inhibitory presynaptic dopamino receptors in the rat anococcygeus muscle that are specifically antagonized by metoclopramide.
V K Patel
Source of Support: None, Conflict of Interest: None