IPSIndian Journal of Pharmacology
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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 122-128

Influence of temperature on the status of histamine receptors in the isolated guinea pig ileum

Correspondence Address:
P K Bhuttani

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Source of Support: None, Conflict of Interest: None

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1. Histamine a non-specific H-receptor agonist & 2 (2-pyridyl) ethylamine (PEA).an H1 receptor agonist produced dose dependent contractions of guinea-pig ileum at 37". 25" and 15 C. 2. The responses were blocked competitively by mepyramine (1 X 10-9 M) at 37oC and 25 C. The antagonism appeared to be non-competitive at 15 C. 3. Ranitidine (1 X 10 -7M) inhibited the responses to histamine at all temperatures. 4. Dimaprit, a specific H2 receptor agonist did not produce any effect at 37C. However at 25C and 15C. it produced a dose dependent contraction and the responses were competitively blocked by rantidine. 5. Our data suggests decrease in H1-receptors and appearance of excitatory H2-receptors at lower temperatures in guinea pigileum. ,


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