| RESEARCH PAPER
|Year : 1988 | Volume
| Issue : 2 | Page : 122-128
Influence of temperature on the status of histamine receptors in the isolated guinea pig ileum
PK Bhuttani, RJ Shah, KR Goyal
1. Histamine a non-specific H-receptor agonist & 2 (2-pyridyl) ethylamine (PEA).an H1 receptor agonist produced dose dependent contractions of guinea-pig ileum at 37". 25" and 15ø C.
2. The responses were blocked competitively by mepyramine (1 X 10-9 M) at 37oC and 25ø C. The antagonism appeared to be non-competitive at 15ø C.
3. Ranitidine (1 X 10 -7M) inhibited the responses to histamine at all temperatures.
4. Dimaprit, a specific H2 receptor agonist did not produce any effect at 37øC. However at 25øC and 15øC. it produced a dose dependent contraction and the responses were competitively blocked by rantidine.
5. Our data suggests decrease in H1-receptors and appearance of excitatory H2-receptors at lower temperatures in guinea pigileum. ,
P K Bhuttani
Source of Support: None, Conflict of Interest: None