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 RESEARCH PAPER
Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 109-113

Histopathological and histochemical changes caused by glyzophrol, an alkylating agent in testis of black rats (Rattus rattus)



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Rani Seema


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1. Test is of 20 mg/kg of Glyzophrol treated rats showed degenerative changes in most of seminiferous tubules. edema in Interstitial tissue. maturation arrest (only spermatogonia and primary spermatocytes and degenerating sperms. 2. After 60 mg/kg of Glvzophrol treatment, the colourof test is turned brownish black due to haemorrhage. Edemain interstitial tissue. Tubular degeneration with loss of normal tubular pattern and exfoliation of degeneration cells intubularlumina. Thickening of basement membrane. Maturation arrest after primary spermatocytes formation in all the seminiferous tubules. call debris and eosinophilic masses in stripe-like-appearance might be the products of degenerating sperms were observed in test is of 60 mg/kg of Glyrophrol treated rats.Testis exhibited depressed alkaline phosphatase activity due to Glyrophrol treatment.






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