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Year : 1987  |  Volume : 19  |  Issue : 3  |  Page : 186-191

Uptake and release of epinephrine in chicken liver: in vitro studies

Correspondence Address:
A K Aggarwal

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Source of Support: None, Conflict of Interest: None

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1. The epinephrine (E) content in white leg horn ( WLH ) chicken liver was estimated to be three-times less then norepinephrine (NE). 2. The liver slices were able to accumulate high concentration of E from the incubation media and this was found to be a concentration and time dependent phenomenon with peak accumulation occuring after 45 min. of incubation at 10-4M concentration of the amine. This process could be significantly blocked by cocaine, metanephrine and phenoxybenzamine. Following maximum accumulation, the amine showed linear disappearance when incubated in amine free media. 3. In tissue slices taken from reserpine treated group, the rate constant of disappearance (K) was much faster, decreasing its half life, as compared to control.


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